DNA repair mechanisms and gametogenesis

DNA repair mechanisms and gametogenesis.

In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but also take part in the meiotic recombination process. Furthermore, the DNA repair mechanisms should tolerate mutations occurring during gametogenesis, to a limited extent. In t...

DNA Repair Pathways and Mechanisms

Our cells are constantly exposed to insults from endogenous and exogenous agents that can introduce damage into our DNA and generate genomic instability. Many of these lesions cause structural damage to DNA and can alter or eliminate fundamental cellular processes, such as DNA replication or transcription. DNA lesions commonly include base and sugar modifications, singleand double-strand breaks...

DNA Damage Response and Repair Mechanisms

The brochure accompanies the symposium and features the consortium and its members. Support by the European Community is gratefully acknowledged.

Synergy Between DNA Replication and Repair Mechanisms

In Vivo Dna Repair Mechanisms and Carcinogenesis

Understanding how DNA repair deficiencies predispose cells to damage accumulation and mutation is particularly important to understanding the carcinogenic process. In the first theme (Theme I) of this work, two types of base excision repair (BER) deficiencies are explored. In the first study (Theme IA), we observed a significant decrease in BER activity in liver tissues during acute hepatitis i...